Structure of PDB 5z57 Chain O

Receptor sequence
>5z57O (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
DFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKT
EVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYT
QNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFW
VKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRAS
TMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQ
CAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWG
3D structure
PDB5z57 Structure of the human activated spliceosome in three conformational states.
ChainO
Resolution6.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033120 positive regulation of RNA splicing
GO:0042307 positive regulation of protein import into nucleus
GO:0045292 mRNA cis splicing, via spliceosome
GO:0046827 positive regulation of protein export from nucleus
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:5z57, PDBe:5z57, PDBj:5z57
PDBsum5z57
PubMed29360106
UniProtQ9NW64|RBM22_HUMAN Pre-mRNA-splicing factor RBM22 (Gene Name=RBM22)

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