Structure of PDB 5z3v Chain O

Receptor sequence

>5z3vO (length=576) Species: 559292 (Saccharomyces cerevisiae S288C)

LLDQTKDTRITHLLRQTNAFLDYYNVAHRIKEDIKKQPSILVGGTLKDYQ
IKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIRGPYLV
IVPLSTLSNWSSEFAKWAPTLRTISFKGSPNERKAKQAKIRAGEFDVVLT
TFEYIIKERALLSKVKWVHMIIDEGHRMKNAQSKLSLTLNTHYHADYRLI
LTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFDKIELSEEETL
LVIRRLHKVLRPFLLRRLKKDVEKELPDKVEKVVKCKMSALQQIMYQQML
KYRGFNNQIMQLKKICNHPFVFEEVEDQINPTRETNDDIWRVAGKFELLD
RILPKLKATGHRVLIFFQMTQIMDIMEDFLRYINIKYLRLDGHTKSDERS
ELLRLFNAPDSEYLCFILSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQA
QDRAHRIGQKNEVRILRLITTNSVEEVILERAYKKLDIDGKVIQAGKFDN
KSTSEEQEALLRSLLDAEEERRKKREEELKDSEINEILARNDEEMAVLTR
MDEDRSKKEKSRLREESESAAVYNGR

3D structure

• PDB: 5z3v Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
• Chain: O
• Resolution: 4.22 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	O	L825 R854 E874 Y875 K878 F1048 N1049 M1112 T1113 G1135 S1162 A1165	L104 R133 E153 Y154 K157 F305 N306 M369 T370 G392 S419 A422
BS02	dna	O	K900 S904 K905 L906 N1186	K179 S183 K184 L185 N443
BS03	ADP	O	T766 K768 Y770 G797 K798 T799 I800 W838 N1171 Q1173 I1200	T45 K47 Y49 G76 K77 T78 I79 W117 N428 Q430 I457
BS04	BEF	O	R1196 R1199	R453 R456

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:5z3v, PDBe:5z3v, PDBj:5z3v
• PDBsum: 5z3v
• PubMed: 30867599
• UniProt: P22082|SNF2_YEAST Transcription regulatory protein SNF2 (Gene Name=SNF2)