Structure of PDB 3ksd Chain O

Receptor sequence

>3ksdO (length=332) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252)

AVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQ
GRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYT
DKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASS
TTNSLAPVAKVLNDDFGLVEGLMTTINAYTGDQNTQDAPHRKGDKRRARA
AAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEK
QDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMS
VGDQLVKVAAWYDNEMSYTAQLVRTLAYLAEL

3D structure

• PDB: 3ksd Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 1 from methicillin-resistant Staphylococcus aureus MRSA252 provides novel insights into substrate binding and catalytic mechanism.
• Chain: O
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	O	G11 R12 I13 D34 L35 P78 C96 T97 G98 F99 S120 N316 Y320	G10 R11 I12 D33 L34 P77 C95 T96 G97 F98 S119 N314 Y318

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0030554 adenyl nucleotide binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3ksd, PDBe:3ksd, PDBj:3ksd
• PDBsum: 3ksd
• PubMed: 20620151
• UniProt: Q6GIL8|G3P1_STAAR Glyceraldehyde-3-phosphate dehydrogenase 1 (Gene Name=gapA1)