Structure of PDB 2v12 Chain O

Receptor sequence
>2v12O (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITV
TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLK
EDVFSFYYNRDSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVS
VGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKC
NEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPT
GPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2v12 Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
ChainO
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C39 O Y20 V36 D38 G40 S41 R82 Y83 T85 A122 V127 I137 D226 G228 A229 Y16 V32 D34 G36 S37 R78 Y79 T81 A118 V123 I133 D217 G219 A220 BindingDB: IC50=0.9nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2v12, PDBe:2v12, PDBj:2v12
PDBsum2v12
PubMed10903938
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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