Structure of PDB 2v11 Chain O

Receptor sequence
>2v11O (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITV
TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLK
EDVFSFYYNRDSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVS
VGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKC
NEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPT
GPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2v11 Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
ChainO
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C80 O T18 Q19 Y20 V36 D38 G40 R82 Y83 S84 T85 L121 A122 I137 D226 T227 G228 A229 S230 T14 Q15 Y16 V32 D34 G36 R78 Y79 S80 T81 L117 A118 I133 D217 T218 G219 A220 S221 BindingDB: IC50=3nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2v11, PDBe:2v11, PDBj:2v11
PDBsum2v11
PubMed10903938
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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