Structure of PDB 2fbw Chain O

Receptor sequence
>2fbwO (length=241) Species: 9031 (Gallus gallus) [Search protein sequence]
TSRIKKFSIYRWDPDKPGDKPRMQTYEVDLNKCGPMVLDALIKIKNELDS
TLTFRRSCREGICGSCAMNIAGGNTLACTKKIDPDLSKTTKIYPLPHMYV
VKDLVPDLSNFYAQYKSIEPYLKKKDESKQGKEQYLQSIEDRQKLDGLYE
CILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDYTEERLAQLQ
DPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEK
3D structure
PDB2fbw 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
ChainO
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FES O C65 R66 G68 C70 G71 S72 C73 C85 C58 R59 G61 C63 G64 S65 C66 C78
BS02 SF4 O C158 I159 L160 C161 A162 C164 A182 C225 C151 I152 L153 C154 A155 C157 A175 C218
BS03 F3S O C168 Y178 P181 C215 T217 I218 M219 N220 C221 C161 Y171 P174 C208 T210 I211 M212 N213 C214
BS04 CBE O W173 H216 W166 H209
Gene Ontology
Molecular Function
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:2fbw, PDBe:2fbw, PDBj:2fbw
PDBsum2fbw
PubMed16371358
UniProtQ9YHT2|SDHB_CHICK Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Gene Name=SDHB)

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