Structure of PDB 2b4t Chain O

Receptor sequence
>2b4tO (length=333) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
TKLGINGFGRIGRLVFRAAFGRKDIEVVAINDPFMDLNHLCYLLKYDSVH
GQFPCEVTHADGFLLIGEKKVSVFAEKDPSQIPWGKCQVDVVCESTGVFL
TKELASSHLKGGAKKVIMSAPPKDDTPIYVMGINHHQYDTKQLIVSNASC
TTNCLAPLAKVINDRFGIVEGLMTTVHASTANQLVVDGPSKGGKDWRAGR
CALSNIIPASTGAAKAVGKVLPELNGKLTGVAFRVPIGTVSVVDLVCRLQ
KPAKYEEVALEIKKAAEGPLKGILGYTEDEVVSQDFVHDNRSSIFDMKAG
LALNDNFFKLVSWYDNEWGYSNRVLDLAVHITT
3D structure
PDB2b4t Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
ChainO
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD O G10 G12 R13 I14 D35 P36 F37 S98 T99 S122 C153 A184 N319 Y323 G7 G9 R10 I11 D32 P33 F34 S95 T96 S119 C150 A181 N316 Y320
BS02 AES O T183 N185 T180 N182
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b4t, PDBe:2b4t, PDBj:2b4t
PDBsum2b4t
PubMed16345073
UniProtQ8T6B1

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