Structure of PDB 2b4r Chain O

Receptor sequence
>2b4rO (length=334) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
ATKLGINGFGRIGRLVFRAAFGRKDIEVVAINDPFMDLNHLCYLLKYDSV
HGQFPCEVTHADGFLLIGEKKVSVFAEKDPSQIPWGKCQVDVVCESTGVF
LTKELASSHLKGGAKKVIMSAPPKDDTPIYVMGINHHQYDTKQLIVSNAS
CTTNCLAPLAKVINDRFGIVEGLMTTVHASTANQLVVDGPSKGGKDWRAG
RCALSNIIPASTGAAKAVGKVLPELNGKLTGVAFRVPIGTVSVVDLVCRL
QKPAKYEEVALEIKKAAEGPLKGILGYTEDEVVSQDFVHDNRSSIFDMKA
GLALNDNFFKLVSWYDNEWGYSNRVLDLAVHITT
3D structure
PDB2b4r Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
ChainO
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD O G10 G12 R13 I14 D35 P36 F37 T99 S122 C153 A184 N319 Y323 G8 G10 R11 I12 D33 P34 F35 T97 S120 C151 A182 N317 Y321
BS02 AES O T183 N185 T181 N183
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b4r, PDBe:2b4r, PDBj:2b4r
PDBsum2b4r
PubMed16345073
UniProtQ8T6B1

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