Structure of PDB 8fkz Chain NL

Receptor sequence
>8fkzNL (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
KPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQDTVER
PFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEV
APAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQ
ESTFQELCEGLLEESDTTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQ
ELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDI
DVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVK
LVEKRAFREIQL
3D structure
PDB8fkz Principles of human pre-60 S biogenesis.
ChainNL
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0042802 identical protein binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001932 regulation of protein phosphorylation
GO:0006281 DNA repair
GO:0006364 rRNA processing
GO:0006974 DNA damage response
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0039535 regulation of RIG-I signaling pathway
GO:0042254 ribosome biogenesis
GO:0042981 regulation of apoptotic process
GO:0050821 protein stabilization
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0071456 cellular response to hypoxia
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1902570 protein localization to nucleolus
GO:1903006 positive regulation of protein K63-linked deubiquitination
GO:1903715 regulation of aerobic respiration
GO:1990173 protein localization to nucleoplasm
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0033553 rDNA heterochromatin
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkz, PDBe:8fkz, PDBj:8fkz
PDBsum8fkz
PubMed37410842
UniProtQ9NZM5|NOP53_HUMAN Ribosome biogenesis protein NOP53 (Gene Name=NOP53)

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