Structure of PDB 7mq8 Chain NK

Receptor sequence
>7mq8NK (length=815) Species: 9606 (Homo sapiens) [Search protein sequence]
MHRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHMLSKATVK
ARPSVLWCYKKDPFELFIAATNIRYCYYNETHKILGNTFGMCVLQDFEAL
TPNLLARTVETVEGGGLVVILLRTMNSLKQLYTVTMDVHSRYRTEAHQDV
VGRFNERFILSLASCKKCLVIDDQLNILPISSHVATMEALPPSDLELREL
KESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTLRSTVALTAARGR
GKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQYQEH
LDYEIIQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVID
EAAAIPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQARTL
YEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELYYV
NRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLL
PPVPPTQNALPEVLAVIQVCLEGEISRQSILNSLSRGDLIPWTVSEQFQD
PDFGGLSGGRVVRIAVHPDYQGMGYGSRALQLLQMYYEGRFPEEVITPRK
DLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPND
LTGEHSCIMLKTLGWLAAFWKDFRRRFLALLSYQFSTFSPSLALNIIQNR
NMGKPAQPALSREELEALFLPYDLKRLEMYSRNMVDYHLIMDMIPAISRI
YFLNQLGDLALSAAQSALLLGIGLQHKSVDQLEKEIELPSGQLMGLFNRI
IRKVVKLFNEVQEKA
3D structure
PDB7mq8 Nucleolar maturation of the human small subunit processome.
ChainNK
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP NK K256 Q260 G287 G289 K290 S291 F325 I469 R470 K218 Q222 G249 G251 K252 S253 F287 I409 R410
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0051392 tRNA N-acetyltransferase activity
GO:0070182 DNA polymerase binding
GO:0106162 mRNA N-acetyltransferase activity
GO:1990883 rRNA cytidine N-acetyltransferase activity
Biological Process
GO:0000154 rRNA modification
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0006473 protein acetylation
GO:0008033 tRNA processing
GO:0010824 regulation of centrosome duplication
GO:0016072 rRNA metabolic process
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0042274 ribosomal small subunit biogenesis
GO:0045727 positive regulation of translation
GO:0051391 tRNA acetylation
GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030496 midbody
GO:0032040 small-subunit processome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
PDBsum7mq8
PubMed34516797
UniProtQ9H0A0|NAT10_HUMAN RNA cytidine acetyltransferase (Gene Name=NAT10)

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