Structure of PDB 8fkx Chain NI

Receptor sequence

>8fkxNI (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]

DGEFEIQLPTFPTSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVIL
DGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQ
TLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVA
VEMSLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATL
PKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFFLVREDTKAAVLLHLL
HNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALDPTARKINL
AKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVAR
AGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLG
RVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESI
KRAKEMDLVGLGLHPLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINAS
SRDLCSQVMRAKRQKDRKAIARFQQGQQGRQEQQEGPDQEFYIPYRPKAF
EQQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFKKIKTESGRYISSSY
KRDLYQKWKQKQ

3D structure

PDB

8fkx Principles of human pre-60 S biogenesis.

Chain

Resolution

2.59 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	NI	E177 G203 R205 H229 D445 P448 Q518 N579 R583 D584 S587 I601 F604 K735 F739 I751 T753 E754 S755 R757 I759 Y763 K770	E96 G122 R124 H148 D364 P367 Q437 N498 R502 D503 S506 I520 F523 K581 F585 I588 T590 E591 S592 R594 I596 Y600 K607
BS02	ADP	NI	Y116 V118 T120 Q123 T142 G143 G145 K146 T147	Y35 V37 T39 Q42 T61 G62 G64 K65 T66

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0004386	helicase activity
GO:0005102	signaling receptor binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0030331	nuclear estrogen receptor binding

	Biological Process
GO:0006364	rRNA processing
GO:0006396	RNA processing
GO:0016070	RNA metabolic process
GO:0030520	estrogen receptor signaling pathway
GO:0045892	negative regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8fkx, PDBe:8fkx, PDBj:8fkx
PDBsum	8fkx
PubMed	37410842
UniProt	Q8TDD1\|DDX54_HUMAN ATP-dependent RNA helicase DDX54 (Gene Name=DDX54)

[Back to BioLiP]