Structure of PDB 8fku Chain NI

Receptor sequence
>8fkuNI (length=598) Species: 9606 (Homo sapiens) [Search protein sequence]
GGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSG
KTACFLLPMFERLKTHSAQTGARALILSPTRELALQTLKFTKELGKFTGL
KTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVEYVV
FDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTE
PVLIRLDVDTKLNEQLKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFV
ATKHHAEYLTELLTTQRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVT
DLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPD
EIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQSVVDEEDSGL
QSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLH
PLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQ
KDRKAIARFQQGQQGRQEQQEGPDQEFYIPYRPKAFEQQAAGAVLDLMGD
EAQNLTRGRQQLKWDRKKKRFKKIKTESGRYISSSYKRDLYQKWKQKQ
3D structure
PDB8fku Principles of human pre-60 S biogenesis.
ChainNI
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna NI D445 N579 D584 S587 F604 T753 E754 S755 Y763 D350 N484 D489 S492 F509 T576 E577 S578 Y586
BS02 ADP NI G145 K146 T147 G50 K51 T52
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030331 nuclear estrogen receptor binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0016070 RNA metabolic process
GO:0030520 estrogen receptor signaling pathway
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8fku, PDBe:8fku, PDBj:8fku
PDBsum8fku
PubMed37410842
UniProtQ8TDD1|DDX54_HUMAN ATP-dependent RNA helicase DDX54 (Gene Name=DDX54)

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