Structure of PDB 8fl0 Chain ND

Receptor sequence
>8fl0ND (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
VVKPKTKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALK
KPYGVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIG
RMYDYHVLDMIELGIENFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDY
RRLKSLLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKSG
CRTPRIELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKALKPKKKKNISH
DTFGTTYGRIHMQKQDLSKL
3D structure
PDB8fl0 Principles of human pre-60 S biogenesis.
ChainND
Resolution2.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna ND P10 K11 R14 R17 F18 Y63 K65 N67 F80 F81 K84 K249 P4 K5 R8 R11 F12 Y57 K59 N61 F74 F75 K78 K243
BS02 rna ND E73 N96 K97 K98 R99 E67 N90 K91 K92 R93
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 maturation of LSU-rRNA
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Cellular Component
External links
PDB RCSB:8fl0, PDBe:8fl0, PDBj:8fl0
PDBsum8fl0
PubMed37410842
UniProtQ9H7B2|RPF2_HUMAN Ribosome production factor 2 homolog (Gene Name=RPF2)

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