Structure of PDB 8fl3 Chain NC

Receptor sequence

>8fl3NC (length=511) Species: 9606 (Homo sapiens) [Search protein sequence]

TINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPL
QYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVV
MKQSKLPMSLLHDRKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIEN
AEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDS
SDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATK
RWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFI
GYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVV
YPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWE
NAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAE
PSHCDANTEMQQILTRVRQNFGKINSGDDLVPVEKIAKYQKFLDKAKAKK
FSAVRISKGLS

3D structure

PDB

8fl3 Principles of human pre-60 S biogenesis.

Chain

Resolution

2.53 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	NC	K16 A17 S18 T19 R23 G26 A27 G28 G29 Q30 R33 R40 R45 R49 R50 N51 R53 A67 S68 G69 K112 K115 K131 H133 I134 K147 Q149 K151 R180 A193 E196 K200 S203 K204 R205 I206 W207 Y211 D258 T262 W263 H282 S284 T286 N287 F289 K291 G292 R299 K309 Q310 K333 V335 P340 G343 K346 W348 Q349 Y350 I351 T352 M354 R355 Y367 P368 V381 Q383 E385 K386 T429 G430 K431 K434 G435 Q441 K445 R453 K617	K6 A7 S8 T9 R13 G16 A17 G18 G19 Q20 R23 R30 R35 R39 R40 N41 R43 A57 S58 G59 K102 K105 K115 H117 I118 K131 Q133 K135 R164 A177 E180 K184 S187 K188 R189 I190 W191 Y195 D242 T246 W247 H266 S268 T270 N271 F273 K275 G276 R283 K293 Q294 K317 V319 P324 G327 K330 W332 Q333 Y334 I335 T336 M338 R339 Y351 P352 V365 Q367 E369 K370 T413 G414 K415 K418 G419 Q425 K429 R437 K499
BS02	GTP	NC	K256 D258 H282 A283 N320 G322 K323 S324 S325 P340 G343 E344 T345	K240 D242 H266 A267 N304 G306 K307 S308 S309 P324 G327 E328 T329
BS03	MG	NC	S324 T345	S308 T329

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005525	GTP binding

	Biological Process
GO:0008150	biological_process
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8fl3, PDBe:8fl3, PDBj:8fl3
PDBsum	8fl3
PubMed	37410842
UniProt	Q13823\|NOG2_HUMAN Nucleolar GTP-binding protein 2 (Gene Name=GNL2)

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