Structure of PDB 8rm5 Chain N

Receptor sequence
>8rm5N (length=834) Species: 9606 (Homo sapiens) [Search protein sequence]
FLGMPAPLGYVPGLGRGATGFTTRSDIGPARDAKDDEEADAIYAALDKRM
DERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPE
VGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGRNTL
MDMRLSQQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPH
HPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDT
AKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLW
KAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKAR
ENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWI
QDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALE
CARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKA
EVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDE
YERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYED
FPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIG
QLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQEC
PNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKI
TKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPR
HGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
3D structure
PDB8rm5 Structural insights into the cross-exon to cross-intron spliceosome switch
ChainN
Resolution6.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna N N168 K169 R175 E177 K178 R826 N106 K107 R113 E115 K116 R719
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rm5, PDBe:8rm5, PDBj:8rm5
PDBsum8rm5
PubMed38778104
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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