Structure of PDB 8qpe Chain N

Receptor sequence
>8qpeN (length=831) Species: 9606 (Homo sapiens) [Search protein sequence]
FLGMPAPLGYVPGLGRGATGFTTRSDIGPAKDDEEADAIYAALDKRMDER
RKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGD
ARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGRNTLMDM
RLSQQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPP
AWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAA
VELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENI
PTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDA
EECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECAR
AIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVL
WLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPK
LWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLT
RARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNS
GILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKA
REWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGE
LWCAVSKDIANWQKKIGDILRLVAGRIKNTF
3D structure
PDB8qpe Structural insights into the cross-exon to cross-intron spliceosome switch
ChainN
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna N N168 K169 R172 R175 Y176 E177 K178 P824 Q825 R826 K829 N103 K104 R107 R110 Y111 E112 K113 P714 Q715 R716 K719
BS02 rna N R111 R115 R116 R119 R120 R123 R46 R50 R51 R54 R55 R58
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qpe, PDBe:8qpe, PDBj:8qpe
PDBsum8qpe
PubMed38778104
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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