Structure of PDB 8pkp Chain N

Receptor sequence
>8pkpN (length=652) Species: 9606 (Homo sapiens) [Search protein sequence]
PGQELLVAWNTVSTGLVPPAPPKEEELRAAVEVLRGHGLHSVLEEWFVEV
LQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRS
LELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYG
CFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDK
QQCWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCR
GEYERSFLREFHKWIERVVGWLGKVFLQDGPARPASPEAGNTLRRWRCHV
QRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSL
KAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYL
RTREDTVRQIVAGLTGSGEPEDWVPDPVDASDIISLLVSIYGSKDLFINE
YRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSR
RINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAA
LEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILL
YFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEE
ER
3D structure
PDB8pkp High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
ChainN
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN N C221 C224 C193 C196
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0007399 nervous system development
GO:0010629 negative regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031915 positive regulation of synaptic plasticity
GO:0045773 positive regulation of axon extension
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0090129 positive regulation of synapse maturation
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pkp, PDBe:8pkp, PDBj:8pkp
PDBsum8pkp
PubMed
UniProtQ9UJX6|ANC2_HUMAN Anaphase-promoting complex subunit 2 (Gene Name=ANAPC2)

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