Structure of PDB 8i7x Chain N

Receptor sequence
>8i7xN (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
IYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGG
VVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSR
IMIHQPIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQ
EFGILDKVLVHPP
3D structure
PDB8i7x Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.
ChainN
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OSR N I100 L104 F105 S108 Y138 I26 L30 F31 S34 Y64
BS02 OSR N I75 E82 I84 Y118 W146 I1 E8 I10 Y44 W72
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8i7x, PDBe:8i7x, PDBj:8i7x
PDBsum8i7x
PubMed37352796
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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