Structure of PDB 8i0u Chain N

Receptor sequence
>8i0uN (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIF
RIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENL
CCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCS
3D structure
PDB8i0u Molecular basis for the activation of human spliceosome
ChainN
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna N G39 R41 Q95 G96 E98 T111 N112 T115 N116 I118 V121 P122 K125 L126 G39 R41 Q95 G96 E98 T111 N112 T115 N116 I118 V121 P122 K125 L126
BS02 ZN N C117 C119 C134 C117 C119 C134
BS03 ZN N C101 C102 C105 C137 C101 C102 C105 C137
BS04 ZN N C101 C139 C142 C101 C139 C142
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016922 nuclear receptor binding
GO:0030374 nuclear receptor coactivator activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:2000825 positive regulation of androgen receptor activity
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0u, PDBe:8i0u, PDBj:8i0u
PDBsum8i0u
PubMed39068178
UniProtP41223|BUD31_HUMAN Protein BUD31 homolog (Gene Name=BUD31)

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