Structure of PDB 8hxx Chain N

Receptor sequence
>8hxxN (length=375) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KELLEKDSKGNIIKLNEPSTISEDSKVSVTGLPLNKGPSEKIKRESLWNY
RKRNDLKTFLTENMTEESNIRSTIGWNDFENEDFCSACNQSGSFLCCDTC
PKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIESNFIK
QNNNVKIFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSDENDK
IPLTDRQLFNTSYGQSITKLDSYNPDTHIDSNSGKFLICYKCNQTRLGSW
SHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKVYKKI
HNYKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIIPTTNSIKYDFFDK
IYKSKMVQKRKLFQFQESLIDKLVS
3D structure
PDB8hxx Structure of histone deacetylase complex Rpd3S bound to nucleosome
ChainN
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide N G270 S271 F272 L273 C274 D276 G92 S93 F94 L95 C96 D98
BS02 ZN N C263 C266 H283 C286 C85 C88 H105 C108
BS03 ZN N C417 C420 H448 C451 C239 C242 H270 C273
BS04 ZN N C275 C278 C303 C306 C97 C100 C125 C128
BS05 ZN N C440 C443 C466 H469 C262 C265 C288 H291
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060195 negative regulation of antisense RNA transcription
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0032221 Rpd3S complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hxx, PDBe:8hxx, PDBj:8hxx
PDBsum8hxx
PubMed37798513
UniProtQ04779|RCO1_YEAST Transcriptional regulatory protein RCO1 (Gene Name=RCO1)

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