Structure of PDB 8hcr Chain N

Receptor sequence

>8hcrN (length=524) Species: 33892 (Mycobacterium tuberculosis variant bovis BCG)

LARQAEDIDTRYHPSAALRRQLNKVFPTHWSFLLGEIALYSFVVLLITGV
YLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEVRGGLFVRQI
HHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFG
YSLPDDLLSGLGLRAALSSITLGMPVIGTWLHWALFGGDFPGTILIPRLY
ALHILLLPGIILALIGLHLALVWFQKHTQFPGPGRTEHNVVGVRVMPVFA
FKSGAFFAAIVGVLGLMGGLLQINPIWNLGPYKPSQVSAGSQPDFYMMWT
EGLARIWPPWEFYFWHHTIPAPVWVAVIMGLVFVLLPAYPFLEKRFTGDY
AHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMNDIIALKFHISLNATT
WIGRIGMVILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRLPHGAY
IELHQPLGPVDEHGHPIPLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSA
AEDAALREAGHAAEQRALAALREH

3D structure

• PDB: 8hcr Cryo-Electron Microscopy Structure of the Mycobacterium tuberculosi s Cytochrome bcc : aa 3 Supercomplex and a Novel Inhibitor Targeting Subunit Cytochrome c I.
• Chain: N
• Resolution: N/A

Enzymatic activity

• Enzyme Commision number: 7.1.1.8: quinol--cytochrome-c reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	N	F45 G48 F121 I125 H128 L129 R131 R142 N145 W146 G149 I228 H231 H240 T241	F32 G35 F108 I112 H115 L116 R118 R129 N132 W133 G136 I215 H218 H227 T228
BS02	HEM	N	L58 G62 V63 F69 R111 H114 H115 E159 G163 P167 H216	L45 G49 V50 F56 R98 H101 H102 E146 G150 P154 H203

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8hcr, PDBe:8hcr, PDBj:8hcr
• PDBsum: 8hcr
• PubMed: 37158740
• UniProt: P9WP37|QCRB_MYCTU Cytochrome bc1 complex cytochrome b subunit (Gene Name=qcrB)