Structure of PDB 8aly Chain N

Receptor sequence
>8alyN (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
DFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRH
KLIKGVERLISGQQGLNPYLTGSGTILIDLSPDDKEFQSVEEEMQSTVRG
GIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHWSPFV
NAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYCPVHKDRSCYICH
RQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPLAEYVIYRGEQAYP
EYLITYQIM
3D structure
PDB8aly Structural basis of tankyrase activation by polymerization.
ChainN
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN N H1084 C1089 H191 C196
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8aly, PDBe:8aly, PDBj:8aly
PDBsum8aly
PubMed36418402
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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