Structure of PDB 7x8x Chain N

Receptor sequence
>7x8xN (length=176) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
LTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYIN
SPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYAL
PHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERI
EADSDRDRWFTAAEALEYGFVDHIIT
3D structure
PDB7x8x structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
ChainN
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide N G69 I71 S98 M99 H123 P125 L126 G127 F143 G54 I56 S83 M84 H108 P110 L111 G112 F128
BS02 AI4 N S72 M75 I146 E149 S57 M60 I131 E134
BS03 AI4 N G94 H117 R119 W174 G79 H102 R104 W159
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7x8x, PDBe:7x8x, PDBj:7x8x
PDBsum7x8x
PubMed
UniProtP9WPC5|CLPP1_MYCTU ATP-dependent Clp protease proteolytic subunit 1 (Gene Name=clpP1)

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