Structure of PDB 7v3x Chain N

Receptor sequence

>7v3xN (length=455) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSLAKLVDFILDASDLSALIERINYAIQKY
RARRVSIDSVTSVFQQYSSVVRRELFRLVARLKQIGATTVMTTERIEEYG
PIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHMKGEYPFTI
TDHGINIFPRLTQRSSNVRVSSGVVRLDEMCGGGFFKDSIILATGATGTG
KTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMDFEEMERQNL
LKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALARGVSNNAFR
QFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHISTITDTIILLQYV
EIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFRNFERIISGS
PTRIT

3D structure

PDB

7v3x Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	N	T290 G291 T292 G293 K294 T295 S330 W331 R451 I472	T247 G248 T249 G250 K251 T252 S287 W288 R408 I429
BS02	ATP	N	G51 K52 T53 I239	G34 K35 T36 I200
BS03	MG	N	E318 D378	E275 D335
BS04	ATP	N	K457 M458 R459 G460 S461 H463	K414 M415 R416 G417 S418 H420
BS05	ATP	N	F199 K224 R226 G227 S229 H230	F160 K185 R187 G188 S190 H191

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7v3x, PDBe:7v3x, PDBj:7v3x
PDBsum	7v3x
PubMed	35427168
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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