Structure of PDB 7s1k Chain N

Receptor sequence

>7s1kN (length=177) Species: 562 (Escherichia coli)

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFR

3D structure

• PDB: 7s1k Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
• Chain: N
• Resolution: 2.42 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	N	S73 V74 A75 R80	S72 V73 A74 R79
BS02	rna	N	T35 N37 M38 G39 V40 G41 T68 A70 R71 K72 V74 F77 I79 I85 K88 S121 F122 D123 N127 S129 M130 R133 G151 D153	T34 N36 M37 G38 V39 G40 T67 A69 R70 K71 V73 F76 I78 I84 K87 S120 F121 D122 N126 S128 M129 R132 G150 D152
BS03	rna	N	S24 Q27 Q63 K64 L66 T90 R92	S23 Q26 Q62 K63 L65 T89 R91

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7s1k, PDBe:7s1k, PDBj:7s1k
• PDBsum: 7s1k
• PubMed: 35165456
• UniProt: P62399|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)