Structure of PDB 7r50 Chain N

Receptor sequence
>7r50N (length=461) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVA
NMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPV
TLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCDRFARVLSDF
VTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTP
AVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDA
IKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMM
TGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMI
GSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSSFDRARKGLFEEGI
STSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQS
AAGFAEGHPLP
3D structure
PDB7r50 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
ChainN
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.7.1.7: GMP reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP N M53 G300 A301 C303 D336 G359 S360 G386 M387 R391 E413 M52 G292 A293 C295 D328 G351 S352 G378 M379 R383 E398
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003920 GMP reductase activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0032264 IMP salvage
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r50, PDBe:7r50, PDBj:7r50
PDBsum7r50
PubMed35338694
UniProtA0QYE8|GUAB1_MYCS2 GMP reductase (Gene Name=guaB1)

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