Structure of PDB 7qwr Chain N

Receptor sequence

>7qwrN (length=203) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSV
AEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWI
TKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLH
RYR

3D structure

PDB

7qwr Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	N	G2 Y4 K5 Q8 W11 R12 K14 Q15 R24 W28 R31 S34 P40 R41 R44 K47 R49 R50 L51 K54 A55 K56 Q57 R65 R67 R68 G69 R71 K72 R73 P74 V75 K77 Y81 G82 K83 P84 V85 H86 H87 V89 N90 Q91 K93 F94 A95 S97 E104 R105 R108 A112 W120 D124 S125 Y127 K128 F138 K140 A141 R144 W150 P154 V155 H156 H158 R162 L164 R169 K170 S171 R172 G173 L174 K176 G177 H178 K179 F180 H181 H182 I184 G185 G186 S187 R189 W192 R193 R195 R202 Y203 R204	G1 Y3 K4 Q7 W10 R11 K13 Q14 R23 W27 R30 S33 P39 R40 R43 K46 R48 R49 L50 K53 A54 K55 Q56 R64 R66 R67 G68 R70 K71 R72 P73 V74 K76 Y80 G81 K82 P83 V84 H85 H86 V88 N89 Q90 K92 F93 A94 S96 E103 R104 R107 A111 W119 D123 S124 Y126 K127 F137 K139 A140 R143 W149 P153 V154 H155 H157 R161 L163 R168 K169 S170 R171 G172 L173 K175 G176 H177 K178 F179 H180 H181 I183 G184 G185 S186 R188 W191 R192 R194 R201 Y202 R203
BS02	rna	N	R38 V60 Y62 H109 D136 H139	R37 V59 Y61 H108 D135 H138

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7qwr, PDBe:7qwr, PDBj:7qwr
PDBsum	7qwr
PubMed	35201867
UniProt	G1T0C1\|RL15_RABIT Large ribosomal subunit protein eL15 (Gene Name=RPL15)

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