Structure of PDB 7npa Chain N

Receptor sequence
>7npaN (length=616) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence]
YEWKLNDIVDNGICAKCGTCTVVCPNGILTFEDRPKLTEECLRKGNGMCF
EVCPRVSSGKYQIKIREKFKEYYYGKGDVEGQDGGVVTTFLKYLLKNKKI
DGAIVVGDECWKPVSLIVQNEEDLMNTTKSKYTVSTLEALKTAGEMGLEK
VAVVGLPCQINGLRKLQYFQYLAKHDGELGKNGKPVKLPKIEYLIGLLCT
EKFEYDELKETLAKYNINMDDVEKFDIKKGKLLVYVNGEEHKIPLKEIEL
SAGCKMCRDFDAEMADVSVGCVGSPDGYSTVIIRTEKGEEIKNAIELKEG
VNLEAIEKLRDLKLNRFKKEVERRKAEDEKVSFYWTADYGGVGKRADGTY
FIRIRAKPAGWYSIDEAREILEIAEKYDGKIKMTNRGAFEIHGISGFDVE
AMVLELMEKGFITGSEGPLVRATLACPGEGNCGSGLINTTELCKILEDNF
KEHPAPYKFKIAISGCPNKCVRPQIHDIGIAGVKFPVVNEENCNGCGRCA
EVCKIEAIDIRGETSYTNYNVCIGCGKCIKACPNEGRDVKEEGFMVYVGG
KTGREVIEGVSMKLMSVEEILNLIDKVLIVYHKYAKKPQRERLAAVMARI
GKGKFLEEVKELMEQN
3D structure
PDB7npa Structures of the sulfite detoxifying F 420 -dependent enzyme from Methanococcales.
ChainN
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.98.3: sulfite reductase (coenzyme F420).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRM N C428 P429 C434 S436 N470 C472 R474 K506 C426 P427 C432 S434 N468 C470 R472 K504
BS02 FAD N G83 Q84 G87 V89 T90 V107 V108 T129 K131 S132 K133 Y134 S137 V156 L158 L200 C201 T202 G272 C273 V274 S281 G81 Q82 G85 V87 T88 V105 V106 T127 K129 S130 K131 Y132 S135 V154 L156 L198 C199 T200 G270 C271 V272 S279
BS03 SF4 N C25 L30 C42 R44 G46 G48 C50 E180 C24 L29 C41 R43 G45 G47 C49 E178
BS04 SF4 N P488 C505 A509 I510 C524 I525 G526 C527 G528 C530 P486 C503 A507 I508 C522 I523 G524 C525 G526 C528
BS05 SF4 N C428 C434 S436 G437 G467 C468 N470 C472 C426 C432 S434 G435 G465 C466 N468 C470
BS06 SF4 N C495 N496 G497 C498 G499 C501 S517 C534 N536 G538 R539 C493 N494 G495 C496 G497 C499 S515 C532 N534 G536 R537
BS07 SF4 N L6 C15 C18 G19 T20 C21 P36 C54 L5 C14 C17 G18 T19 C20 P35 C53
BS08 SF4 N A16 R56 P159 C160 C201 K204 C256 C259 A15 R55 P157 C158 C199 K202 C254 C257
BS09 SF4 N R56 P159 C160 C201 T202 E203 C256 C259 K315 R55 P157 C158 C199 T200 E201 C254 C257 K313
BS10 FAD N Q84 D85 G86 G87 V88 V89 S132 K133 Y134 V156 L158 L199 L200 C201 T202 F262 V271 G272 C273 V274 S281 Q82 D83 G84 G85 V86 V87 S130 K131 Y132 V154 L156 L197 L198 C199 T200 F260 V269 G270 C271 V272 S279
BS11 SRM N F353 R355 K384 T386 N387 R388 E392 Y459 K460 K462 K553 T554 G555 R556 R594 F351 R353 K382 T384 N385 R386 E390 Y457 K458 K460 K551 T552 G553 R554 R592
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0052592 oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

View graph for
Molecular Function
External links
PDB RCSB:7npa, PDBe:7npa, PDBj:7npa
PDBsum7npa
PubMed36658338
UniProtA0A2Z5PF12

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