Structure of PDB 6wc2 Chain N

Receptor sequence
>6wc2N (length=53) Species: 9606 (Homo sapiens) [Search protein sequence]
RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRY
KSK
3D structure
PDB6wc2 Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
ChainN
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna N R142 Y162 R168 Q187 Y191 R1 Y21 R27 Q46 Y50
BS02 dna N R142 F145 Q181 W185 N188 R1 F4 Q40 W44 N47
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6wc2, PDBe:6wc2, PDBj:6wc2
PDBsum6wc2
PubMed32681840
UniProtP52952|NKX25_HUMAN Homeobox protein Nkx-2.5 (Gene Name=NKX2-5)

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