Structure of PDB 6uwr Chain N

Receptor sequence
>6uwrN (length=660) Species: 1496 (Clostridioides difficile) [Search protein sequence]
EDLDTDNDNIPDSYERNGYTIKDLIAVKWEDSFAEQGYKKYVSNYLESNT
AGDPYTDYEKASGSFDKAIKTEARDPLVAAYPIVGVGMEKLIISTNEHAS
TDQGKTVSRATTNSKTESNTAGVSVNVGYQNGFTANVTTNYSHTTDNSTA
VQDSNGESWNTGLSINKGESAYINANVRYYNTGTAPMYKVTPTTNLVLDG
DTLSTIKAQENQIGNNLSPGDTYPKKGLSPLALNTMDQFSSRLIPINYDQ
LKKLDAGKQIKLETTQVSGNFGTKNSSGQIVTEGNSWSDYISQIDSISAS
IILDTENESYERRVTAKNLQDPEDKTPELTIGEAIEKAFGATKKDGLLYF
NDIPIDESCVELIFDDNTANKIKDSLKTLSDKKIYNVKLERGMNILIKTP
TYFTNFDDYNNYPSTWSNVNTTNQDGLQGSANKLNGETKIKIPMSELKPY
KRYVFSGYSKDPLTSNSIIVKIKAKEEKTDYLVPEQGYTKFSYEFETTEK
DSSNIEITLIGSGTTYLDNLSITELNSTPEILDEPEVKIPTDQEIMDAHK
IYFADLNFNPSTGNTYINGMYFAPTQTNKEALDYIQKYRVEATLQYSGFK
DIGTKDKEMRNYLGDPNQPKTNYVNLRSYFTGGENIMTYKKLRIYAITPD
DRELLVLSVD
3D structure
PDB6uwr Structure of the cell-binding component of theClostridium difficilebinary toxin reveals a di-heptamer macromolecular assembly.
ChainN
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA N D222 D224 E231 N260 E263 D273 D6 D8 E15 N44 E47 D57
BS02 CA N D220 D222 D224 I226 E231 D4 D6 D8 I10 E15
BS03 CA N N621 D623 Q644 G645 S646 D734 N405 D407 Q428 G429 S430 D518
Gene Ontology
Biological Process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:6uwr, PDBe:6uwr, PDBj:6uwr
PDBsum6uwr
PubMed31896582
UniProtO32739

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