Structure of PDB 6tm5 Chain N

Receptor sequence
>6tm5N (length=676) Species: 9606 (Homo sapiens) [Search protein sequence]
RPGQELLVAWNTVSTGLVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQ
NDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRSLE
LLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTR
ERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFNTLRRWRCHVQRFFYR
IYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALET
RLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDT
VRQIVAGLTSGEPEDWVPDPVDSDIISLLVSIYGSKDLFINEYRSLLADR
LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIRE
EDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKY
EQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASW
TLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDN
MVLIKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDL
QELQGYLQKKVRDQQLVYSAGVYRLP
3D structure
PDB6tm5 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
ChainN
Resolution3.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide N N392 D395 Q806 N308 D311 Q664
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0007399 nervous system development
GO:0010629 negative regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031915 positive regulation of synaptic plasticity
GO:0045773 positive regulation of axon extension
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0090129 positive regulation of synapse maturation
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6tm5, PDBe:6tm5, PDBj:6tm5
PDBsum6tm5
PubMed32307883
UniProtQ9UJX6|ANC2_HUMAN Anaphase-promoting complex subunit 2 (Gene Name=ANAPC2)

[Back to BioLiP]