Structure of PDB 6qg0 Chain N

Receptor sequence
>6qg0N (length=408) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
IINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFLERNITIKLGYANAK
IYKCQESFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLS
GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMRE
ESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPP
RDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIR
PGIVTKDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLC
RADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEV
LMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRL
IGWATIKK
3D structure
PDB6qg0 Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
ChainN
Resolution4.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A110 K113 S114 T137 H197
Catalytic site (residue number reindexed from 1) A17 K20 S21 T41 H91
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide N Q248 V251 R255 E256 Q263 I280 P282 S284 L287 Y289 Q142 V145 R149 E150 Q157 I174 P176 S178 L181 Y183
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031369 translation initiation factor binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Cellular Component
External links
PDB RCSB:6qg0, PDBe:6qg0, PDBj:6qg0
PDBsum6qg0
PubMed31201334
UniProtP32481|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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