Structure of PDB 6pch Chain N

Receptor sequence

>6pchN (length=206) Species: 562 (Escherichia coli)

MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAIQV
TTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEFTVGQSISVEL
FADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNG
KVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSDLIV
KPAVKA

3D structure

• PDB: 6pch Synthetic group A streptogramin antibiotics that overcome Vat resistance.
• Chain: N
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	N	M11 P23 Q36 N42 Y45 Q49 K56 R59 T61 K62 P63 G66 H67 K70 L79 E81 S113 K114 G115 K116 G117 F118 G120 K123 R124 F127 R128 T129 Q130 A132 T133 H134 G135 S137 L138 S139 H140 R141 P143 S145 I146 G147 Q148 N149 G153 K154 V155 F156 K157 G158 K159 K160 M161 A162 Q164 R169 T171 Q173 S174 A192 V193 P194 T197 K208	M11 P23 Q36 N42 Y45 Q49 K56 R59 T61 K62 P63 G66 H67 K70 L79 E81 S113 K114 G115 K116 G117 F118 G120 K123 R124 F127 R128 T129 Q130 A132 T133 H134 G135 S137 L138 S139 H140 R141 P143 S145 I146 G147 Q148 N149 G150 K151 V152 F153 K154 G155 K156 K157 M158 A159 Q161 R166 T168 Q170 S171 A189 V190 P191 T194 K205

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6pch, PDBe:6pch, PDBj:6pch
• PDBsum: 6pch
• PubMed: 32968273
• UniProt: P60438|RL3_ECOLI Large ribosomal subunit protein uL3 (Gene Name=rplC)