Structure of PDB 5lez Chain N

Receptor sequence
>5lezN (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
TTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAA
DTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIII
AGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKE
ECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVA
TL
3D structure
PDB5lez The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
ChainN
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1 D17 R19 K33 G47 S130 D167 S170
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S130 D167 S170
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide N T1 T20 T21 T31 R45 G47 A49 S169 T1 T20 T21 T31 R45 G47 A49 S169
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lez, PDBe:5lez, PDBj:5lez
PDBsum5lez
PubMed27493187
UniProtP28072|PSB6_HUMAN Proteasome subunit beta type-6 (Gene Name=PSMB6)

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