Structure of PDB 5epi Chain N

Receptor sequence
>5epiN (length=756) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence]
MNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYS
NKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHP
GLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSF
RLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFL
IKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRG
FVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISM
TVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIAR
LGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEG
TASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFV
NAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGF
VSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLF
IADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNL
RNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITKMDYD
AVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKP
VGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEIGYIGSGSG
ENLYFQ
3D structure
PDB5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
ChainN
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna N H32 G33 T34 Y38 M356 K365 E384 L674 N675 H32 G33 T34 Y38 M356 K365 E384 L667 N668
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5epi, PDBe:5epi, PDBj:5epi
PDBsum5epi
PubMed26711008
UniProtQ5V8Y6

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