Structure of PDB 1nmb Chain N

Receptor sequence
>1nmbN (length=388) Species: 11320 (Influenza A virus) [Search protein sequence]
REFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRF
YALSQGTTIRGKHSNGTIHDRSQYRDLISWPLSSPPTVYNSRVECIGWSS
TSCHDGRARMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESEC
VCQNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLTGTAKHIEECSC
YGEQAGVTCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPND
PTVGKCNDPYPGNNNNGVKGFSYLDGGNTWLGRTISIASRSGYEMLKVPN
ALTDDRSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGR
PKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL
3D structure
PDB1nmb The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody
ChainN
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R292 Y406
Catalytic site (residue number reindexed from 1) R212 Y324
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA N T391 G394 T310 G312
BS02 MAN N R364 E375 R283 E294
BS03 MAN N D330 K389 D250 K308
BS04 MAN N R327 N329 D330 I366 I368 R247 N249 D250 I285 I287
BS05 CA N D293 G297 D324 N347 D213 G217 D244 N266
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0033644 host cell membrane
GO:0044423 virion component
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nmb, PDBe:1nmb, PDBj:1nmb
PDBsum1nmb
PubMed7994573
UniProtP05803|NRAM_I84A1 Neuraminidase (Gene Name=NA)

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