Structure of PDB 1dx5 Chain N

Receptor sequence
>1dx5N (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFIENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
3D structure
PDB1dx5 Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex
ChainN
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0GJ N W215 G216 W227 G228
BS02 0GJ N H57 L99 H43 L96
BS03 0GJ N H57 D189 A190 S195 W215 G216 H43 D199 A200 S205 W227 G228
BS04 0GJ N H57 S195 H43 S205
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1dx5, PDBe:1dx5, PDBj:1dx5
PDBsum1dx5
PubMed10761923
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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