Structure of PDB 7qvp Chain MX

Receptor sequence

>7qvpMX (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]

KKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESA
MKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKA
YVRLAPDYDALDVANKIGII

3D structure

PDB

7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	MX	P49 L52 R55 K63 R67 N69 K70 Q108	P13 L16 R19 K27 R31 N33 K34 Q72
BS02	rna	MX	K39 P44 T45 R47 R48 K50 T51 R53 R56 Q57 P58 K59 Y60 R62 T83 E84 S85 N93 N105 K106 H107 K123 N125 T126 L127 I128 P130 K134 K135 Y137 R139	K3 P8 T9 R11 R12 K14 T15 R17 R20 Q21 P22 K23 Y24 R26 T47 E48 S49 N57 N69 K70 H71 K87 N89 T90 L91 I92 P94 K98 K99 Y101 R103

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0045296	cadherin binding
GO:1904841	TORC2 complex binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum	7qvp
PubMed	36302773
UniProt	P62750\|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)