Structure of PDB 7qvp Chain MP

Receptor sequence

>7qvpMP (length=153) Species: 9606 (Homo sapiens)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

3D structure

• PDB: 7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
• Chain: MP
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	MP	R3 S5 R61 R62 W78 N120 K121 P123 H145	R2 S4 R60 R61 W77 N119 K120 P122 H144
BS02	rna	MP	V2 R3 Y4 K16 R18 S20 H25 K27 R30 K37 K43 R62 Y63 G65 G66 G68 R69 A71 K74 Q75 W78 Q80 R82 W83 P84 K85 K86 N97 S100 N101 L104 H116 Q118 V119 R127 Y130 R131 A132 H133 R135 I136 P138 Y139 M140 S141	V1 R2 Y3 K15 R17 S19 H24 K26 R29 K36 K42 R61 Y62 G64 G65 G67 R68 A70 K73 Q74 W77 Q79 R81 W82 P83 K84 K85 N96 S99 N100 L103 H115 Q117 V118 R126 Y129 R130 A131 H132 R134 I135 P137 Y138 M139 S140

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
• PDBsum: 7qvp
• PubMed: 36302773
• UniProt: P18621|RL17_HUMAN Large ribosomal subunit protein uL22 (Gene Name=RPL17)