Structure of PDB 7qvp Chain MN

Receptor sequence

>7qvpMN (length=203) Species: 9606 (Homo sapiens)

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSV
AEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWI
TKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLH
RYR

3D structure

• PDB: 7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
• Chain: MN
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	MN	R38 Q57 V60 Y62 H109 C110 D136	R37 Q56 V59 Y61 H108 C109 D135
BS02	rna	MN	G2 Y4 Q8 W11 R12 K14 Q15 R24 R31 P40 R41 R44 K47 R49 R50 K54 A55 K56 Q57 R65 R67 R68 G69 G70 K72 P74 V75 K77 G78 Y81 G82 K83 P84 V85 H86 H87 N90 Q91 K93 F94 A95 R96 V101 R105 R108 A112 N117 S125 Y127 F138 R144 W150 H156 H158 R159 M161 R162 L164 R169 S171 R172 G173 K176 H178 K179 F180 H181 I184 G185 G186 S187 R188 R189 W192 R193 R194 R195 H201 R202 R204	G1 Y3 Q7 W10 R11 K13 Q14 R23 R30 P39 R40 R43 K46 R48 R49 K53 A54 K55 Q56 R64 R66 R67 G68 G69 K71 P73 V74 K76 G77 Y80 G81 K82 P83 V84 H85 H86 N89 Q90 K92 F93 A94 R95 V100 R104 R107 A111 N116 S124 Y126 F137 R143 W149 H155 H157 R158 M160 R161 L163 R168 S170 R171 G172 K175 H177 K178 F179 H180 I183 G184 G185 S186 R187 R188 W191 R192 R193 R194 H200 R201 R203

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0044391 ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
• PDBsum: 7qvp
• PubMed: 36302773
• UniProt: L8Y0W1