Structure of PDB 7qvp Chain ML

Receptor sequence

>7qvpML (length=204) Species: 9606 (Homo sapiens)

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQ

3D structure

• PDB: 7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
• Chain: ML
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	ML	F26 A30 R34	F25 A29 R33
BS02	rna	ML	A2 S4 R5 M8 L10 K11 P12 H13 F14 H15 K16 W18 R20 Q28 P29 R31 K32 I33 R35 R36 R39 K42 R44 R56 V59 R60 P62 T63 R65 Y66 H67 R71 G73 R74 K88 K89 R92 D99 P100 R101 R102 R103 K105 R129 K135 R158 K163 K165 F179 R183 M184 R186 A187 G193 I194 R195 K197 R198	A1 S3 R4 M7 L9 K10 P11 H12 F13 H14 K15 W17 R19 Q27 P28 R30 K31 I32 R34 R35 R38 K41 R43 R55 V58 R59 P61 T62 R64 Y65 H66 R70 G72 R73 K87 K88 R91 D98 P99 R100 R101 R102 K104 R128 K134 R157 K162 K164 F178 R182 M183 R185 A186 G192 I193 R194 K196 R197

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
• PDBsum: 7qvp
• PubMed: 36302773
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)