Structure of PDB 8p2k Chain MA

Receptor sequence
>8p2kMA (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
DINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQA
LKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVH
LACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVNI
TLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRE
LGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSG
HVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEIL
TRRLDSARPHFMSQF
3D structure
PDB8p2k NAC controls cotranslational N-terminal methionine excision in eukaryotes.
ChainMA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna MA R289 K311 W335 R218 K240 W264
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006417 regulation of translation
GO:0006508 proteolysis
GO:0018206 peptidyl-methionine modification
GO:0031365 N-terminal protein amino acid modification
GO:0051604 protein maturation
GO:0070527 platelet aggregation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p2k, PDBe:8p2k, PDBj:8p2k
PDBsum8p2k
PubMed37347872
UniProtP53582|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)

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