Structure of PDB 8y36 Chain M

Receptor sequence

>8y36M (length=119) Species: 1280 (Staphylococcus aureus)

MISKIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKG
VTLAQASSKDSDIATTATKVELATKVGEAIAKKAADKGIKEIVFDRGGYL
YHGRVKALAEAARESGLEF

3D structure

• PDB: 8y36 Synthetic macrolides overcoming MLS B K-resistant pathogens.
• Chain: M
• Resolution: 2.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	M1 I2 R14 R17 T20 L22 F94 R96 L100 Y101	M1 I2 R14 R17 T20 L22 F94 R96 L100 Y101
BS02	rna	M	K4 D6 K7 R11 R19 R30 N32 Y34 R35 S36 N37 H39 Q43 T52 Q55 K59 A67 T68 K69 V70 H102 G103 R104	K4 D6 K7 R11 R19 R30 N32 Y34 R35 S36 N37 H39 Q43 T52 Q55 K59 A67 T68 K69 V70 H102 G103 R104

Gene Ontology

Molecular Function

• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8y36, PDBe:8y36, PDBj:8y36
• PDBsum: 8y36
• PubMed: 38992047
• UniProt: Q7A085|RL18_STAAW Large ribosomal subunit protein uL18 (Gene Name=rplR)