Structure of PDB 8uk9 Chain M

Receptor sequence
>8uk9M (length=317) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSP
SPGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGR
QKVIVIDEFCRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQS
RCRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKN
FPDFRKTIGELDSYSSKGVLDAGILSLVTNDAIDDVLESLKNKDVKQLRA
LAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTE
LHLAYLFIQLACEMQWK
3D structure
PDB8uk9 Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
ChainM
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M K80 I81 R85 R111 G113 K80 I81 R85 R111 G113
BS02 MG M T57 E108 T57 E108
BS03 AF3 M P52 K56 E108 N139 R205 P52 K56 E108 N139 R205
BS04 ADP M E12 R16 P17 C23 I24 P52 T54 G55 K56 T57 T58 F204 R205 E12 R16 P17 C23 I24 P52 T54 G55 K56 T57 T58 F204 R205
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uk9, PDBe:8uk9, PDBj:8uk9
PDBsum8uk9
PubMed38177685
UniProtP04526|LOADL_BPT4 Sliding-clamp-loader large subunit (Gene Name=44)

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