Structure of PDB 8tvy Chain M

Receptor sequence
>8tvyM (length=558) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DDEEEENDDKILKELEDLRFRGQPGEAKDDGDELYYQERLKKWVKQRSCG
SQRSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYEL
YQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATVMKQW
CNEFQHWWPPLRTVILHSMGSGMASDHILITTYVGLRIHSDKLLKVKWQY
AVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFDFI
FPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYL
LRRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRN
VLFGIDILRKICNHPDLLDRDTKRHNPDYGDPKRSGKMQVVKQLLLLWHK
QGYKALLFTQSRQMLDILEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLV
DRFNNESFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAW
RIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIH
ELHDLFSL
3D structure
PDB8tvy Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
ChainM
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M K253 R452 N476 S479 E480 N504 N535 K709 W752 F794 L798 I814 H815 H818 K42 R187 N211 S214 E215 N239 N270 K444 W487 F529 L533 I549 H550 H553
BS02 dna M T447 V449 N611 K613 S676 R677 R731 V732 T182 V184 N346 K348 S411 R412 R466 V467
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 DNA damage response
GO:0061635 regulation of protein complex stability
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tvy, PDBe:8tvy, PDBj:8tvy
PDBsum8tvy
PubMed38194460
UniProtP40352|RAD26_YEAST DNA repair and recombination protein RAD26 (Gene Name=RAD26)

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