Structure of PDB 8q48 Chain M

Receptor sequence
>8q48M (length=459) Species: 9913 (Bos taurus) [Search protein sequence]
MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSL
NFSLLFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLI
SLQLFLIMTFTAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFL
FYTLAGSLPLLVALIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACM
MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMLRITLIL
NPMTDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVA
ILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQT
LLPLMATWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNM
VITALYSLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLN
PKIILGPLY
3D structure
PDB8q48 Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I
ChainM
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN M H82 E335 H338 H82 E335 H338
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0048039 ubiquinone binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0032981 mitochondrial respiratory chain complex I assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Cellular Component
External links
PDB RCSB:8q48, PDBe:8q48, PDBj:8q48
PDBsum8q48
PubMed38870289
UniProtP03910|NU4M_BOVIN NADH-ubiquinone oxidoreductase chain 4 (Gene Name=MT-ND4)

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