Structure of PDB 8jfl Chain M

Receptor sequence
>8jflM (length=970) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSIL
AVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESF
KYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTASG
LHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASSVGMA
KAALEALLADEVQHCQSILNSLLPRASTSKEVDASLLSVVSFPAFAVEDS
QLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFEN
IECEWPLFWTYFILDGVFSGNAEQVQEYKEALEAVLKNGVPLLPELYSVP
PDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFLAPGEIDPL
NRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPA
RILSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFTFTPQFID
QQQFYLALDNKMIVEMLRTDLSYLCSRWRMTGQPTITFPISHSMLDEDGT
SLNSSILAALRKMQDGYFGGARVQTGKLSEFLTTSCCTHLSFMDPGSGEV
DFKALVLQLKEQADILYMLYTMKGPDWTELYNERSATVRELLTELYGKVG
EIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHLTVGLPPEPREKTIS
APLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAEMFRL
RIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHHILSGKEFQ
GQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSVEGFVLPSSTTREMT
PGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIEIHSIGSIIAV
EKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPSGRFGTMT
YLSKAAATYVQEFLPHSICA
3D structure
PDB8jfl Architecture and activation of human muscle phosphorylase kinase
ChainM
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAR M K1081 L1137 A1207 A1208 V1211 S1218 C1220 K830 L886 A956 A957 V960 S967 C969
Gene Ontology
Molecular Function
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0045819 positive regulation of glycogen catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005964 phosphorylase kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jfl, PDBe:8jfl, PDBj:8jfl
PDBsum8jfl
PubMed38548794
UniProtP46020|KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Gene Name=PHKA1)

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