Structure of PDB 8ir3 Chain M

Receptor sequence

>8ir3M (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

3D structure

PDB

8ir3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

3.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	R20 R21 G23 Y39 G62 R63 M64 R65 H66 L67 K68 R72 F74 H76 R79 G81 T82 T83 P84 P86 K87	R19 R20 G22 Y38 G61 R62 M63 R64 H65 L66 K67 R71 F73 H75 R78 G80 T81 T82 P83 P85 K86
BS02	rna	M	T2 K3 T5 S6 F8 G9 R11 R12 N13 K14 T15 H16 H28 Q30 R43 K44 R45 K46 Y47 N48 W49 K52 R55 R56 Y71 E80 G81	T1 K2 T4 S5 F7 G8 R10 R11 N12 K13 T14 H15 H27 Q29 R42 K43 R44 K45 Y46 N47 W48 K51 R54 R55 Y70 E79 G80

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding
GO:0046872	metal ion binding
GO:0097371	MDM2/MDM4 family protein binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:1901798	positive regulation of signal transduction by p53 class mediator

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8ir3, PDBe:8ir3, PDBj:8ir3
PDBsum	8ir3
PubMed	37491604
UniProt	P61927\|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)