Structure of PDB 8a98 Chain M

Receptor sequence

>8a98M (length=203) Species: 347515 (Leishmania major strain Friedlin)

GAFMYLNELWKKKSSDVMRFIQRIRSWEFRHQHTVVRLRRPTRPEKARML
GYKTKQGFCVFRVRVRRGGRKRPVHKGITYGKPKTSGVLGMKLNKNNQAV
AEQRLGKRFGNLRVLNSYWVNMDSTFKWYEVIAVDPMCKTIRRDPRINWI
VNSVHKHREQRGLTSAGRKHRGLRHKGHKASKLRPSYRAAWRRNNRIVFL
RKR

3D structure

• PDB: 8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
• Chain: M
• Resolution: 2.46 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	G2 F4 K12 K14 H34 T35 R40 R41 R44 K47 R49 M50 K54 T55 K56 R67 R68 R71 K77 G82 K83 P84 K85 G91 M92 K93 L94 N95 K96 N97 R105 N112 N117 M138 K140 T141 R147 W150 S154 H158 Q161 R162 R169 K170 H171 R172 H176 K177 G178 H179 K180 K183 R185 Y188 W192 R193 R194 N195 R202 R204	G1 F3 K11 K13 H33 T34 R39 R40 R43 K46 R48 M49 K53 T54 K55 R66 R67 R70 K76 G81 K82 P83 K84 G90 M91 K92 L93 N94 K95 N96 R104 N111 N116 M137 K139 T140 R146 W149 S153 H157 Q160 R161 R168 K169 H170 R171 H175 K176 G177 H178 K179 K182 R184 Y187 W191 R192 R193 N194 R201 R203
BS02	rna	M	R31 K72 P74 K77 I79 T80 V89 L90 S125	R30 K71 P73 K76 I78 T79 V88 L89 S124
BS03	rna	M	R38 Q57 F110 N112 D136	R37 Q56 F109 N111 D135

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8a98, PDBe:8a98, PDBj:8a98
• PDBsum: 8a98
• PubMed: 38722744
• UniProt: Q4Q6S3