Structure of PDB 7w5r Chain M

Receptor sequence
>7w5rM (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSE
DVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFY
TLVREIRKHKE
3D structure
PDB7w5r Structural basis of the oncogenic KRAS mutant and GJ101 complex.
ChainM
Resolution3.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG M K16 S17 D57 K16 S17 D57
BS02 GDP M A11 V12 G13 G15 K16 P34 K117 A11 V12 G13 G15 K16 P34 K110
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5r, PDBe:7w5r, PDBj:7w5r
PDBsum7w5r
PubMed36516586
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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